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Träfflista för sökning "WFRF:(Zhang Qiang) ;pers:(Zhang Li);lar1:(ki)"

Search: WFRF:(Zhang Qiang) > Zhang Li > Karolinska Institutet

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  • 2019
  • Journal article (peer-reviewed)
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  • Georgiou, Konstantinos, et al. (author)
  • Genetic basis of PD-L1 overexpression in diffuse large B-cell lymphomas
  • 2016
  • In: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 127:24, s. 3026-3034
  • Journal article (peer-reviewed)abstract
    • Diffuse large B-cell lymphoma (DLBCL) is one of the most common and aggressive types of B-cell lymphoma. Deregulation of proto-oncogene expression after a translocation, most notably to the immunoglobulin heavy-chain locus (IGH), is one of the hallmarks of DLBCL. Using whole-genome sequencing analysis, we have identified the PD-L1/PD-L2 locus as a recurrent translocation partner for IGH in DLBCL. PIM1 and TP63 were also identified as novel translocation partners for PD-L1/PD-L2. Fluorescence in situ hybridization was furthermore used to rapidly screen an expanded DLBCL cohort. Collectively, a subset of samples was found to be affected by gains (12%), amplifications (3%), and translocations (4%) of the PD-L1/PD-L2 locus. RNA sequencing data coupled with immunohistochemistry revealed that these cytogenetic alterations correlated with increased expression of PD-L1 but not of PD-L2. Moreover, cytogenetic alterations affecting the PD-L1/PD-L2 locus were more frequently observed in the non-germinal center B cell-like (non-GCB) subtype of DLBCL. These findings demonstrate the genetic basis of PD-L1 overexpression in DLBCL and suggest that treatments targeting the PD-1-PD-L1/PD-L2 axis might benefit DLBCL patients, especially those belonging to the more aggressive non-GCB subtype.
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  • Result 1-3 of 3
Type of publication
journal article (3)
Type of content
peer-reviewed (3)
Author/Editor
Zhang, Yan (1)
Korhonen, Laura (1)
Lindholm, Dan (1)
Kelly, Daniel (1)
Vertessy, Beata G. (1)
Bengtsson-Palme, Joh ... (1)
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Nilsson, Henrik (1)
Kelly, Ryan (1)
Li, Ying (1)
Moore, Matthew D. (1)
Wang, Mei (1)
Wang, Xin (1)
Liu, Yang (1)
Berglund, Mattias (1)
Enblad, Gunilla (1)
Sundström, Christer (1)
Kumar, Rakesh (1)
Wang, Dong (1)
Liu, Fang (1)
Li, Ke (1)
Liu, Ke (1)
Zhang, Yang (1)
Zhang, Yao (1)
Jin, Yi (1)
Raza, Ali (1)
Rafiq, Muhammad (1)
Zhang, Kai (1)
Pan-Hammarstrom, Qia ... (1)
Khatlani, T (1)
Nàgy, Péter (1)
Kahan, Thomas (1)
Kominami, Eiki (1)
van der Goot, F. Gis ... (1)
Sörelius, Karl, 1981 ... (1)
Bonaldo, Paolo (1)
Batra, Jyotsna (1)
Teixeira, Manuel R (1)
Roobol, Monique J (1)
Adams, Christopher M (1)
Minucci, Saverio (1)
Vellenga, Edo (1)
Backman, Lars (1)
Yan, Hong (1)
Swärd, Karl (1)
Nilsson, Per (1)
Schmidt, Axel (1)
Lorkowski, Stefan (1)
Thrift, Amanda G. (1)
De Milito, Angelo (1)
Zhang, Wei (1)
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University
Karolinska Institutet  (3)Undo refine
Uppsala University (2)
Stockholm University (2)
Lund University (2)
University of Gothenburg (1)
Umeå University (1)
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Halmstad University (1)
Linköping University (1)
Chalmers University of Technology (1)
Swedish University of Agricultural Sciences (1)
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Language
English (3)
Research subject (UKÄ/SCB)
Medical and Health Sciences (3)
Natural sciences (2)

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